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Relationship between serum ferritin and total body iron stores in idiopathic haemochromatosis



Relationship between serum ferritin and total body iron stores in idiopathic haemochromatosis



Gut 19(6): 538-542



The relationship between the serum ferritin concentration and total body Fe stores was investigated in 41 patients with idiopathic hemochromatosis and 199 1st or 2nd degree relatives. Thirty-two relatives (16.1%) had increased Fe stores and serum ferritin levels were increased in all but 1 of them. The false-positive rate in the relatives with normal Fe stores was 1.8% compared with 10% for the serum Fe concentration and 33% for the transferrin saturation. There was a significant correlation between the serum ferritin concentration and both the chelatable body Fe and the hepatic Fe concentration. In the natural history of classical idiopathic hemochromatosis the serum ferritin concentration is usually raised when hepatic Fe stores are increased and before there is architectural damage to the liver.

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Accession: 000734039

Download citation: RISBibTeXText

PMID: 680587

DOI: 10.1136/gut.19.6.538


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