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Relationship between thermogenic drinking and plasma renin activity in the rat



Relationship between thermogenic drinking and plasma renin activity in the rat



Aviation, Space, and Environmental Medicine 50(7): 721-724



The spontaneous water intake of rats increases when they are transferred abruptly from a cold (5.degree. C) to a neutral (25.degree. C) environment. This has been termed thermogenic drinking. Treatment of cold-acclimated rats with SQ 14,225 [3-mercapto-2-D-methylpropanoyl-L-proline], an angiotensin converting enzyme inhibitor, at 10-50 mg/kg body wt prior to removal from cold, inhibited the thermogenic drinking response in a dose-dependent manner. Plasma for determination of plasma renin activity (PRA) was obtained by cardiac puncture from methoxyflurane-anesthetized rats maintained chronically at both 25.degree. and 5.degree. C. Plasma was obtained from cold-acclimated rats 15 min after removal from 5.degree.-25.degree. C. PRA values were 2.2 .+-. 0.4 (SE) ng/ml per h for control rats; 1.9 .+-. 0.8 ng/ml per h for cold-acclimated rats and 8.5 .+-. 1.7 ng/ml per h for cold-acclimated rats removed from cold for 15 min. Thus, PRA was significantly increased in rats removed acutely from cold. Thermogenic drinking may be mediated by the renin-angiotensin system.

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Accession: 000734128

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PMID: 384990


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