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Relationship of free fatty acids and magnesium in ethanol withdrawal in dogs

Relationship of free fatty acids and magnesium in ethanol withdrawal in dogs

Metabolism Clinical & Experimental 28(8): 858-865

A group of dogs was conditioned to drink 4-6 g ethanol/kg per day for long periods. Ethanol ingestion was interrupted at monthly intervals to study some metabolic changes of the withdrawal period. Plasma long chain free fatty acids (FFA) increased by a maximum mean of 1.4 meq/l (3-fold), and Mg decreased by a maximum mean of 0.4 meq/l (75% of control) during the first 24 h of simple ethanol withdrawal. Because Mg salts of FFA are very insoluble, these divergent changes of Mg and FFA suggest that lipolysis may be responsible for the hypomagnesemia that occurs in ethanol withdrawal. No control lipolysis, glucose-insulin, glucose alone, and fructose alone were given i.v. for a 4 h period beginning 14 h after withdrawal. FFA fell by a maximum of 65% or 0.44 meq/l and Mg fell by a maximum of 0.31 meq/l during the glucose-insulin infusions. Nicotinic acid (10-20 mg/kg) in saline produced an identical drop in FFA and a slight rise in Mg. After stopping the nicotinic acid infusion, a sharp rebound rise in FFA and a sharp fall in Mg occurred similar to the simple withdrawal experiments. The sharp divergent changes in FFA and Mg after cessation of nicotinic acid infusion support the prime role of FFA-effecting movements of Mg and the thesis that FFA bind Mg. Control of lipolysis is theoretically sound in therapy of the ethanol withdrawal syndrome.

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Accession: 000734208

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PMID: 572225

DOI: 10.1016/0026-0495(79)90213-0

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