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Renal CaBP and calcium excretion in phosphorus depleted rats

Renal CaBP and calcium excretion in phosphorus depleted rats

Hormone and Metabolic Research 11(5): 377-378

For 2 weeks 3 groups of rats 7 weeks old were given a diet with only 0.03% phosphorus. From weaning they were given a diet deficient in vitamin D without or with 15 or 30 IU cholecalciferol by mouth daily. Calcium-binding protein in kidney cortex was almost undetectable in rats deprived of vitamin D but was present in significant amounts in rats given cholecalciferol. Ca in urine was 9.9 mg/24 h in deprived rats and 14.7 and 13.3 mg/24 h in those given cholecalciferol. The increase in cholecalciferol intake from 15 to 30 IU was associated with an increase in serum Ca and a decrease in urine Ca and fraction of filtered Ca excreted.

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Accession: 000734965

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PMID: 225251

DOI: 10.1055/s-0028-1095782

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