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Studies on the mechanism of action of econazole. 2. Effect of econazole on cytoplasmic membranes of fungal, bacterial and mammalian cells



Studies on the mechanism of action of econazole. 2. Effect of econazole on cytoplasmic membranes of fungal, bacterial and mammalian cells



Japanese Journal of Medical Mycology 20(3): 201-208



Econazole induced leakage of intracellular K+, 260 nm-absorbing materials and proteins from Candida albicans protoplasts in the presence of osmotic stabilizer. Econazole also induced release of haemoglobin from human erythrocytes. The extent of K+ release from protoplasts increased with increasing drug concs. Release of K+ and haemoglobin were antagonized by human serum and egg lecithin.

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