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Trichinella spiralis: effects on the host-parasite relationship in mice of BCG (attenuated Mycobacterium bovis)



Trichinella spiralis: effects on the host-parasite relationship in mice of BCG (attenuated Mycobacterium bovis)



Experimental Parasitology 44(2): 181-189



A total of 2 X 107 colony forming units of BCG given intravenously to mice one week before infection with Trichinella spiralis delayed the expulsion of adult worms from the gut. The suppression of adult worm elimination was proportional to the dose of BCG given. This finding was associated with a reduction in the degree of partial villous atrophy induced in the small bowel by T. spiralis. Despite the prolongation of fecund adult worms in the gut, there were no significant differences in muscle larval counts 4 and 6 weeks after infection. When newborn larvae were cultivated in vitro and injected intravenously, there was a significant 25% reduction in larval numbers recovered from the muscles of BCG-treated mice 4 weeks later. The administration of BCG had no effect on the inflammatory reaction around larvae in the muscles 4 and 6 weeks after infection. It is concluded that BCG alters the host-parasite relationship producing retention of adult worms in the gut, reduction in the severity of partial villous atrophy, and increased nonspecific resistance to the systemic larval phase.

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Accession: 000791747

Download citation: RISBibTeXText

PMID: 350600

DOI: 10.1016/0014-4894(78)90096-6



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