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25-Hydroxycholecalciferol and 24,25-dihydroxycholecalciferol in tissues of rats given excess vitamin D

25-Hydroxycholecalciferol and 24,25-dihydroxycholecalciferol in tissues of rats given excess vitamin D

Voprosy Pitaniya (3): 45-48

25-Hydroxycholecalciferol (25-HCC) and 24,25-dihydroxycholecalciferol (24,25-DHCC) were estimated in tissues of rats of bodyweight 200 g given 10 to 250 000 IU cholecalciferol. The rats were killed 2 and 24 h after they had been given by vein radioactively labelled cholecalciferol. 25-HCC in blood plasma, liver, kidneys, bones and muscles, but not in small intestine, increased 4 and 24 h after calciferol injection; the increases were greatest in bones and muscles.

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