Characterization of antigens from Aspergillus fumigatus. V. Reactivity in immunodiffusion tests with serums from patients with aspergillosis caused by Aspergillus flavus, A. niger, and A fumigatus

Chaparas, S.T.; Kaufman, L.; Kim, S.J.; McLaughlin, D.W.

American Review of Respiratory Disease 122(4): 647-650


ISSN/ISBN: 0003-0805
PMID: 6776857
DOI: 10.1164/arrd.1980.122.4.647
Accession: 000837482

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Antigen-rich mycelial extract (ME) and fractions of A. fumigatus were compared with culture filtrates of A. fumigatus, A flavus and A. niger for their abilities to detect antibody in sera from patients with confirmed A. infection due to these spp. In double diffusion tests, homologous antigen preparations were more effective than heterologous preparations in detecting precipitins. ME of A. fumigatus was more effective than A. fumigatus culture filtrate in detecting antibody in sera from patients with A. flavus and A. niger infection. It did not detect antibody in sera from approx. 1/2 those with heterologous infections.