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Chemotherapy of onchocerciasis: a controlled clinical trial of topical diethylcarbamazine (DEC) in Guatemala



Chemotherapy of onchocerciasis: a controlled clinical trial of topical diethylcarbamazine (DEC) in Guatemala



Tropenmedizin und Parasitologie 31(3): 357-364



Fifty-six adult patients in Guatemala infected with Onchocerca volvulus were treated with a lotion containing 2% diethylcarbamazine citrate all over their bodies daily for 7 days and then weekly for 7 weeks. Their reactions were compared in a blind clinical trial with those of 61 similar people treated by a placebo. In both groups the number of microfilariae (mf) in skin snips fell steeply in the first week and then rose very slightly.

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Accession: 000838857

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PMID: 7003855


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