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Corpus luteum function after indomethacin treatment during the estrous cycle and following hysterectomy in the gilt



Corpus luteum function after indomethacin treatment during the estrous cycle and following hysterectomy in the gilt



Biology of Reproduction 25(3): 511-518



Indomethacin (IND), a prostaglandin synthetase inhibitor, was used to determine the relationship between prostaglandin (PG) secretion and corpus luteum (CL) function during the luteal phase of the estrous cycle and after hysterectomy in the gilt. In experiment 1, gilts that had displayed estrous cycles of 18-22 days (onset of estrus = day 0) were randomly assigned to 4 treatments (7/group): ethanol vehicle (EtOH) daily from days 10-17; IND daily from days 10-17; IND daily from days 10-13 and EtOH daily from days 14-17 and EtOH daily from days 10-13 and IND daily from days 14-17. In experiment 2, 15 gilts were hysterectomized on days 6-10 of the estrous cycle and were randomly assigned to a control (7) or IND-treated (8) group. Treatment, daily for 4 days, began when all gilts had reached day 18 or later. The daily dose of 10 mg IND/kg body wt was calculated on the average body weight of each treatment group. In experiment 1, ovarian morphology at necropsy on day 25, serum progesterone and 13,14-dihydro-15-keto prostaglandin F2.alpha. (PGFM) concentrations throughout the experimental period, and failure to display estrus by day 25 suggest that IND treatment during the luteal phase of the estrous cycle prolonged CL maintenance in the pig. The progesterone and PGFM assays were validated in the laboratory. In experiment 2, CL morphology and serum progesterone and luteinizing hormone (LH) concentrations indicate that IND treatment failed to affect luteal function by a direct action on the luteal cell or by suppressing pituitary LH secretion.

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Accession: 000848704

Download citation: RISBibTeXText

PMID: 7197994

DOI: 10.1095/biolreprod25.3.511


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