+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Correction for the metabolic exchange of 14C for 12C atoms in the pathway of gluconeogenesis in vivo



Correction for the metabolic exchange of 14C for 12C atoms in the pathway of gluconeogenesis in vivo



Federation Proceedings 41(1): 104-109



Methods designed for estimation of the synthesis of plasma glucose are based on the transfer of 14C atoms from a selected precursor (substrate) such as lactate or alanine. This approach resulted in an underestimation of the true synthesis of glucose because of the metabolic exchange of 14C atoms for 12C atoms in the hepatic oxaloacetate pool. From the incorporation of 14C atoms from intravenously infused cetate into plasma glucose, the extent of the metabolic exchange was estimated.

(PDF emailed within 1 workday: $29.90)

Accession: 000848722

Download citation: RISBibTeXText

PMID: 7056394


Related references

Correction for metabolic exchange in the calculation of the rate of gluconeogenesis in rats. Biochemical Medicine 29(3): 372-378, 1983

Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man. Journal of Clinical Investigation 80(5): 1303-1310, 1987

Gluconeogenesis: A teaching pathway. Criteria to establish a metabolic pathway. Journal of Chemical Education 53(2): 86-91, 1976

Correction of tricarboxylic acid cycle exchange in gluconeogenesis: why the y's are wrong. American Journal of Physiology 261(5 Pt 1): E673-E676, 1991

Use of (2)H(2)O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchange. American Journal of Physiology. Endocrinology and Metabolism 303(11): E1304-E1312, 2013

Gluconeogenesis in vivo: correction factors for interaction with the Krebs Cycle. Medical Science Research 16(6): 293-294, 1988

Gluconeogenesis, an essential metabolic pathway for pathogenic Francisella. Molecular Microbiology 98(3): 518-534, 2016

Gluconeogenesis A crucial metabolic pathway for neonatal glucose homeostasis. M-S (Medecine Sciences) 9(3): 297-306, 1993

Effect of metabolic acidosis on renal gluconeogenesis in vivo. American Journal of Physiology 215(1): 211-217, 1968

Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes 58(12): 2766-2775, 2009

The exchange of H and D atoms between water and protein in vivo and in vitro. Acta Physiologica 77(2): 107-122, 1937

The exchange of H and D atoms between water and protein in vivo and in vitro. Acta Physiologica 78(1): 225-241, 1938

An in vivo study of the effect of chronic metabolic acidosis on renal gluconeogenesis. Experientia 25(2): 160-161, 1969

Correction factor for the estimation of plasma glucose synthesis from the transfer of carbon 14 atoms from labeled substrate in vivo. Canadian Journal of Physiology & Pharmacology 57(7): 767-770, 1979

Transfer of the 1-pro-R and the 1-pro-S hydrogen atoms of ethanol in metabolic reductions in vivo. European Journal of Biochemistry 70(1): 83-87, 1976