Effects of a standardized wheat bran preparation on biliary lipid composition and bile acid metabolism in young healthy males

Huijbregts, A.W.; Van Berge-Henegouwen, G.P.; Hectors, M.P.; Van Schaik, A.; Van der Werf, S.D.

European Journal of Clinical Investigation 10(6): 451-458

1980


ISSN/ISBN: 0014-2972
PMID: 6265222
DOI: 10.1111/j.1365-2362.1980.tb02084.x
Accession: 000873084

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Abstract
The effects of adding bran to the normal diet on biliary lipid composition and bile acid metabolism was studied in a group of young healthy males. A chemically standardized coarse wheat bran product, with serum lipid lowering properties, in a dose of 0.5 kg- body wt per day was used. Bran feeding for 4 or 8 wk did not change biliary lipid and biliary bile acid composition. Fecal bile acid and neutral sterol composition was similar before and after 8 wk of bran. Bile acid kinetics, measured by double isotope dilution after simultaneous injection of [3H]cholic acid and [14C]deoxycholic acid, showed minor differences before and during bran ingestion. An increase in 7.alpha.-dehydroxylation fraction (input of deoxycholic acid divided by synthesis of cholic acid) was found in 6 of 7 subjects after 4 wk of bran and in all 4 subjects after 8 wk of bran. The bran product used is not effective in lowering the biliary cholesterol saturation in healthy young males nor does it reduce deoxycholate input in these subjects after 8 wk.

Effects of a standardized wheat bran preparation on biliary lipid composition and bile acid metabolism in young healthy males