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Effects of parathyroid hormone and calcitonin on plasma and nephrogenous cyclic adenosine-3',5'-monophosphate in normal subjects and in pathological conditions



Effects of parathyroid hormone and calcitonin on plasma and nephrogenous cyclic adenosine-3',5'-monophosphate in normal subjects and in pathological conditions



European Journal of Clinical Investigation 10(2 Pt 1): 99-105



To evaluate the response of bone cells and kidney to parathyrin (PTH) and calcitonin (CT), the acute effects of these hormones given by vein on plasma cyclic adenosine 3',5'-monophosphate (cAMP), nephrogenous cAMP and clearance ratio (cAMP:creatinine) were studied in normal subjects and in patients with Paget's disease, hypoparathyroidism and osteopetrosis (marble bone disease); 25 subjects were given bovine synthetic PTH, 38 calcitonin (16 salmon, 18 human and 4 porcine CT).

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Accession: 000875132

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PMID: 6257524



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