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Essential fatty acid status in cystic fibrosis and the effects of safflower oil supplementation



Essential fatty acid status in cystic fibrosis and the effects of safflower oil supplementation



American Journal of Clinical Nutrition 34(1): 1-7



The fatty acid compositions of serum phospholipids, cholesteryl esters, triglycerides, and free fatty acids were determined in cystic fibrosis patients. These were compared with similar data from random hospitalized patients of the same age groups of both sexes. Fatty acid patterns in all lipid classes were skewed in the direction of essential fatty acid deficiency, but the differences were most dramatic in phospholipids. Many calculated parameters useful as indices of essential fatty acid status indicated that essential fatty acid deficiency exists in cystic fibrosis. Treatment of 11 cystic fibrosis patients with safflower oil (1 g/kg per day) failed to correct the aberrations in fatty acid pattern. There may be an impairment in conversion of linoleate to arachidonate and an impairment of absorption.

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Accession: 000880538

Download citation: RISBibTeXText

PMID: 7446449

DOI: 10.1093/ajcn/34.1.1


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