+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Histological changes elicited in Schistosoma japonicum infected rabbits following curative chemotherapy with 4-isothiocyano-4'-nitro-diphenylamine (C9333-Go/CGP 4540)



Histological changes elicited in Schistosoma japonicum infected rabbits following curative chemotherapy with 4-isothiocyano-4'-nitro-diphenylamine (C9333-Go/CGP 4540)



Transactions of the Royal Society of Tropical Medicine and Hygiene 75(3): 415-417



Twenty-six weeks after infection with 250 or 500 Schistosoma japonicum cercariae (Philippine-Leyte strain), 8 of 19 rabbits were given a single curative dose of 25 mg/kg body-weight of CGP 4540. None of the 7 treated rabbits that survived harboured worms at autopsy 6 weeks after treatment. Liver and intestinal granulomata were greatly diminished in size in the treated rabbits.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 000902319

Download citation: RISBibTeXText

PMID: 7324109


Related references

Recovery of the hepatic drug-metabolizing capacity in mice infected with Schistosoma mansoni following curative chemotherapy with the schistosomicide 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540). American Journal of Tropical Medicine and Hygiene 27(6): 1188-1191, 1978

The prophylactic and curative activity of a nitrothiazole derivative, 1-(5-nitro-2-thiazolyl)-2-imidazolidinone, in rhesus monkeys experimentally infected with Schistosoma mansoni and in mice infected with S. japonicum. Acta Tropica. Supplementum 9: 69-77, 1966

Antischistosomal activity of a nitrodiphenylaminoisothiocyanate (C 9333-Go/CGP 4540) against Schistosoma japonicum (Philippine strain) in mice and rabbits. Advances in pharmacology and therapeutics Volume 10 Chemotherapy Proc 7th Internat Congr Pharmacology, Paris 1978: 9-16, 1979

Radioimmunoassay for an antischistosomal drug, 4-nitro-4'-isothiocyano-diphenylamine (7505). Yao Xue Xue Bao 15(8): 463-469, 1980

Experimental pulmonary embolism with schistosoma japonicum eggs 2. pulmonary lesions in rabbits infected with schistosoma japonicum. Kurume Medical Journal 31(2): 47-54, 1984

Histological and histochemical studies of non-infected and infected Oncomelania (Hupensis) quadrasi Davis with Schistosoma japonicum Katsurada, 1904. Philippine Journal of Science. 1979 ; 1081-2: 65-117, 1980

Cellular responses elicited by challenged schistosomula of Schistosoma japonicum in the skin of naive and chronically infected mice. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 7(4): 259-262, 1989

Circulating antigen in rabbits infected with schistosoma japonicum. Japanese Journal of Parasitology 23(1): 37-38, 1974

Renal lesions in Schistosoma japonicum infected rabbits. Transactions of the Royal Society of Tropical Medicine and Hygiene 66(3): 505-507, 1972

Reagin formation in the rabbits infected with schistosoma japonicum. Japanese Journal of Parasitology 24(1 Suppl.): 28, 1975

Serum IgG, IgM, and C3 levels in Schistosoma japonicum infected rabbits. Microbios 48(194): 37-41, 1986

Antigenic substance in the faeces of rabbits infected with Schistosoma japonicum. Journal of the Kurume Medical Association. Dept. of Parasitology, Kurume Univ. School of Medicine, Japan, 34: 9, 886-888, 1971