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Host -- protozoa -- drug interactions in targeted chemotherapy



Host -- protozoa -- drug interactions in targeted chemotherapy



The host invader interplay Proc 3rd Internat Symp on the biochemistry of parasites and host parasite relationships, Beerse, Belgium, 30 June to 3 July 1980: 575-582



Attempts to improve delivery of chemotherapeutic agents to tissues which have been invaded by intracellular protozoal parasites are summarized. The use of liposomes as carriers of chemotherapeutic agents is discussed. Liposome formulations of standard antimonials (meglumine antimoniate and sodium stibogluconate) have enhanced effectiveness some 600- to 700-fold over neat drugs. These antimonial laden liposomes enter parasitized liver cells and undergo degradation with liberation of drug.

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