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Human monocyte killing of a multicellular organism

Human monocyte killing of a multicellular organism

Current chemotherapy and infectious disease Volume 2 Proc 11th Internat Congr of chemotherapy and the 19th Intersci Conf on antimicrobial agents and chemotherapy, Boston, Ma, 1-5 Oct 1979: 1111-1112

Monocytes from uninfected or lightly Schistosoma mansoni-infected people killed 11 to 12% of schistosomula in pooled control plasma after 24 h. With heavily infected people however, killing was reduced to about 4%. Immune plasma increased the killing of schistosomula in all groups but with heavy infections killing remained depressed, suggesting a primary cellular defect. From hepatosplenic patients, monocytes showed poor killing rates (2.4%) in 5 and augmented rates (18.5%) in 6 others.

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Accession: 000903696

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