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Humoral immune reactivity to feline leukemia virus and associated antigens in cats naturally infected with feline leukemia virus



Humoral immune reactivity to feline leukemia virus and associated antigens in cats naturally infected with feline leukemia virus



Cancer Research 40(10): 3642-3651



The humoral antibody response of cats infected with feline leukemia virus (FeLV) was measured by an enzyme-linked immunosorbent assay. Persistently viremic cats developed lower antibody levels than did cats which recovered from the infection. Cats that were viremic for 2-36 wk prior to recovery had variable enzyme-linked immunosorbent assay values that overlapped with the values seen in nonviremic and persistently viremic cats. There was a strong correlation between antibody levels against FeLV and antibodies to feline oncornavirus-associated cell membrane antigen in sera from cats which recovered from FeLV infection but not in sera from cats that were persistently viremic. Sera from persistently viremic and recovered cats were analyzed by gel electrophoresis and enzyme-linked immunosorbent assay. Sera from recovered cats contained antibodies reactive against the 5 major FELV structural proteins (gp73, p27, p15, p12, p10) and against 8 additional antigenic components with apparent MW values of 58,000, 47,000, 36,000, 24,000, 17,000, 15,700, 12,000 and 8500. The major antibody reactivity was directed against the 58,000-dalton protein. Sera from persistently viremic cats also contained antibodies to all of these components but at a significantly reduced level. The 17,000- and 15,700-dalton proteins were cross-reactive with a monoclonal antibody to the p15(E) of murine leukemia virus, and the 47,000-dalton protein appeared to be antigenically related to actin. The 58,000-, 36,000- and 24,000-dalton species contained gag gene homology as judged by their cross-reactivity with sera specific for gag proteins. Feline oncornavirus-associated cell membrane antigen reference sera exhibited high reactivity against p15(E). Antibodies specific for not only gp73 but also for gag gene-coded proteins and polyproteins are important in protection against FeLV infection.

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Accession: 000903818

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PMID: 6254637



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