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Hybridoma antibody immunoassays for the detection of parasitic infection: further studies on a monoclonal antibody with immunodiagnostic potential for Schistosomiasis japonica



Hybridoma antibody immunoassays for the detection of parasitic infection: further studies on a monoclonal antibody with immunodiagnostic potential for Schistosomiasis japonica



Acta Tropica 38(4): 437-447



Trials using a mouse hybridoma-derived antibody (IPH.134-18-6) to Schistosoma japonicum whole worm extract, and sera from infected mice, rabbits and humans, indicate that the antibody has diagnostic potential. In solid-phase radioimmunoassay the binding of labelled hybridoma antibody to the worm extract is inhibited in sera from >90% of infected people. No false positives have been seen. The serum inhibitor is probably an IgG antibody.

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Accession: 000903997

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PMID: 6123249



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