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Research on nitro derivatives of biological interest. XXII. Comparison of the activity against bacteria and protozoa of methoxy or halogen derivatives of nitrobenzofuran and nitronaphthofuran



Research on nitro derivatives of biological interest. XXII. Comparison of the activity against bacteria and protozoa of methoxy or halogen derivatives of nitrobenzofuran and nitronaphthofuran



European Journal of Medicinal Chemistry 16(1): 73-76



The activities of five 2-nitrobenzofurans and twelve 2-nitronaphthofurans against bacteria and protozoa were investigated. Of the 17 compounds tested, 11 showed in vitro activity against Trichomonas vaginalis comparable to (or superior to in 2 cases) metronidazole; only 2 compounds were inactive. 2 compounds were more active in vitro against Entamoeba histolytica than metronidazole and 3 showed comparable activity. 6 others showed not insignificant activity, but 6 were totally inactive.

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Related references

Study of nitro derivatives of biological interest. XXXII. Comparison of antibacterial and parasiticidal activities of 2-nitro and 3-nitrobenzofuran derivatives. European Journal of Medicinal Chemistry, Chimie Therapeutique 18(4): 365-367, 1983

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