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Resistance to Trypanosoma brucei in mice following inoculation of NTG-treated trypanosomes



Resistance to Trypanosoma brucei in mice following inoculation of NTG-treated trypanosomes



American Journal of Tropical Medicine and Hygiene 30(5): 952-954



N-Methyl-N'-nitro-N-nitrosoguanidine (NTG) is an alkylating agent which induces mutations in DNA like those produced by irradiation. T. brucei were suspended in NTG for 15 min and then washed and injected into mice. Surviving mice were reinjected with NTG-treated trypanosomes at 7- to 14-day intervals for a total of 4 injections. After 35 and 88 days the mice were challenged with normal homologous trypanosomes.

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Accession: 000969976

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PMID: 6116437



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