Role of prolactin in amino acid uptake by the lactating mammary gland of the rat

Viña, J.; Puertes, I.R.; Saez, G.T.; Viña, J.R.

FEBS Letters 126(2): 250-252


ISSN/ISBN: 0014-5793
PMID: 6113165
DOI: 10.1016/0014-5793(81)80253-0
Accession: 000973160

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Arteriovenous differences of amino acids across the mammary gland were measured in Wistar rats at days 0, 5, 10, 15 and 20 of lactation. Differences increased from day 0, were max. at days 10-15 and decreased sharply by day 20. Arteriovenous differences were then compared in groups of rats at 10-15 days of lactation which were untreated, given bromocriptine at 10 mg/kg body wt. intraperitoneally (i.p.) to induce prolactin deficiency, or treated with bromocriptine (10 mg/kg, i.p.) and then prolactin (2 mg, i.p.) 2 and 9 h later. Bromocriptine alone caused a decrease in arteriovenous difference but the addition of prolactin resulted in values similar to those from the control group, with the exception of 4 amino acids, where an unexplained decrease still occurred. Results are compared with those of studies on mammary gland gamma -glutamyl transferase during lactation [see DSA 41, 7686, 43, 2859, 3555], and a physiologically important role for prolactin in regulating amino acid uptake by the mammary gland is suggested.