+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc



Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc



American Journal of Clinical Nutrition 34(4): 475-482



The change in the concentration of plasma zinc after oral administration of zinc was used as the index of zinc absorption in the study of the interaction of zinc and iron in the human intestine. With zinc sulfate as the source of inorganic zinc, and ferrous sulfate as the source of nonheme iron, a ratio of Fe/Zn of 1:1 slightly inhibited zinc absorption while Fe/Zn ratio of 2:1 and 3:1 substantially inhibited zinc uptake. No effect on zinc absorption was observed, however, when heme iron, as heme chloride, was ingested in a 3:1 Fe/Zn ratio with inorganic zinc. Atlantic oysters providing about 54 mg of zinc were consumed with or without 100 mg of ferrous iron; Fe/Zn ratio was 2:1. With this 'organic' form of zinc, iron did not significantly affect zinc absorption. The evidence for competitive interation of zinc and iron was strongest with nonheme iron and inorganic zinc. Thus, the possibility that intrinsic iron in formulas for feeding infants and in vitamin-mineral supplements might inhibit the absorption of zinc justifies concern about the Fe/Zn ratio in the formulation of these products.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 000990449

Download citation: RISBibTeXText

PMID: 7223699

DOI: 10.1093/ajcn/34.4.475


Related references

Studies on the bioavailability of zinc in humans: mechanism of the intestinal interaction of nonheme iron and zinc. Journal of Nutrition 113(2): 337-349, 1983

Initial uptake and absorption of nonheme iron and absorption of heme iron in humans are unaffected by the addition of calcium as cheese to a meal with high iron bioavailability. American Journal of Clinical Nutrition 76(2): 419-425, 2002

Zinc inhibits nonheme iron bioavailability in humans. BiologicalTraceElementResearch117(1-3):7, 2007

Effect of heme and nonheme iron on the absorption of inorganic zinc in man. Gastroenterology 76(5 Part 2): 1252, 1979

Studies on the bioavailability of zinc in humans ix. interaction of beef zinc with iron calcium and lactose. Nutrition Research 11(5): 429-438, 1991

Nonheme iron absorption apparent iron absorption and hemoglobin regeneration efficiency in anemic and normal rats fed with dietary heme and nonheme iron at various levels. Nutrition Research 9(7): 773-784, 1989

Studies on the bioavailability of zinc in man. III. Effects of ascorbic acid on zinc absorption. American Journal of Clinical Nutrition 32(12): 2495-2499, 1979

Studies on the effects of dietary zinc dose on zinc 65 absorption in vivo and on the effects of zinc status on zinc 65 absorption and body loss in young rats. British Journal of Nutrition 57(1): 35-44, 1987

Inclusion of guava enhances non-heme iron bioavailability but not fractional zinc absorption from a rice-based meal in adolescents. Journal of Nutrition 143(6): 852-858, 2013

Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. American Journal of Clinical Nutrition 53(1): 112-119, 1991

Conflicting evidence of iron and zinc interactions in humans: does iron affect zinc absorption?. American Journal of Clinical Nutrition 78(6): 1226; Author Reply 1226-7, 2003

Heme and nonheme iron absorption by humans with the C282Y and H63D HFE mutations associated with hemochromatosis. FASEB Journal 16(4): A22-A23, 2002

Heme and Nonheme Iron Absorption in Humans Heterozygous for the C282Y HFE Mutation Associated with Hemochromatosis. FASEB Journal 18(4-5): Abst 500 3, 2004

Acute inhibition of iron bioavailability by zinc: studies in humans. Biometals 25(4): 657-664, 2012

Effect of tea on the bioavailability of nonheme iron, copper, zinc and magnesium in Wistar rats. Archives of Physiology & Biochemistry 104(4): D112, 1996