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The 1-hr blood xylose test in the evaluation of malabsorption in infants and children

The 1-hr blood xylose test in the evaluation of malabsorption in infants and children

American Journal of Clinical Nutrition 33(11): 2328-2333

One h blood xylose absorption tests (197) with 5 g of D-xylose were performed on 171 infants and children for the evaluation of malabsorption. The mean .+-.1 SD blood xylose level in 78 controls was 37.0 .+-. 7.7 mg/dl and in 71 patients with post infectious diarrhea was 28.4 .+-. 11.0 mg/dl. A significant reduction (P < 0.001) was found in 10 patients with Celiac disease (12.0 .+-. 8.6 mg/dl) and 18 patients with intractable diarrhea syndromes (18.3 .+-. 12.5 mg/dl). patients (44) had a blood xylose level < 20 mg/dl and the majority (35/44) were in the groups with postinfection and intractable diarrhea syndromes. Multiple tests were performed on 20 patients. Intestinal biopsies (62) were correlated with 1 h blood xylose levels. The rate of false positives was 0. The rate of false negative tests varied between 4-32.7% depending on the assessment of intestinal damage. The 1 h blood xylose absorption test is a sensitive indicator of severe intestinal damage. Intestinal biopsy should be considered in all patients with a 1 h blood xylose level < 20 mg/dl. With borderline results (20-25 mg/dl), clinical decisions must be individualized.

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Accession: 000998449

Download citation: RISBibTeXText

PMID: 7435413

DOI: 10.1093/ajcn/33.11.2328

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