EurekaMag.com logo
+ Translate

The prevention of alcoholic fatty liver using dietary supplements: dihydroxyacetone, pyruvate and riboflavin compared to arachidonic acid in pair-fed rats


, : The prevention of alcoholic fatty liver using dietary supplements: dihydroxyacetone, pyruvate and riboflavin compared to arachidonic acid in pair-fed rats. Lipids 16(1): 43-51

Male Sprague-Dawley rats were fed for 30 days a high-fat liquid ethanol diet with dihydroxyacetone, pyruvate and riboflavine added as supplements (AMA). Plasma triglyceride (TG) levels were 6-fold greater in these rats than in those fed and alcohol with or without the supplements (AA). The liver TG content in rats fed the AMA diet was similar to that of rats fed a control diet (CA) in which alcohol was replaced with isocaloric amounts of dextrose. Livers of rats fed the AA diet had 3 times more TG than controls. Alcohol ingestion enhanced the hepatic content of cholesteryl esters (CE) and phospholipids (PL). These lipids were reduced to levels found in livers of rats fed the CA diet when dihydroxyacetone, pyruvate and riboflavine were included in the alcohol diet. The fatty acid compositions of TG, CE and PL from livers of rats fed the AMA diet were similar to those of corresponding lipids from rats fed the CA diet but differed from compositions when fed the AA diet. Regardless of the diet fed, TG had the same fatty acid composition in plasma and liver. The same was true of PL fatty acid composition. However, the fatty acid composition of CE differed between liver and plasma. The major fatty acid in liver CE was 18:1 whereas in plasma it was arachidonic acid (20:4). Reduced fatty liver was observed in an earlier study when rats were fed ad lib an ethanol diet containing 20:4. The same diet was pair-fed and fatty liver was not reduced. Dihydroxyacetone, pyruvate and riboflavine did not prevent alcohol-induced fatty liver when 20:4 was included in the AMA diet. Dietary dihydroxyacetone, pyruvate and riboflavine apparently prevent alcohol-induced fatty liver; this effect may result from increased mobilization of fat from liver.

Accession: 001015128

PMID: 7219080

DOI: 10.1007/bf02534920

Download PDF Full Text: The prevention of alcoholic fatty liver using dietary supplements: dihydroxyacetone, pyruvate and riboflavin compared to arachidonic acid in pair-fed rats


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Goheen S.C.; Pearson E.E.; Larkin E.C.; Rao G.A., 1981: The prevention of alcoholic fatty liver using dietary supplements di hydroxy acetone pyruvate and riboflavine compared to arachidonic acid in pair fed rats. Male Sprague-Dawley rats were fed for 30 days a high-fat liquid ethanol diet with dihydroxyacetone, pyruvate and riboflavine added as supplements (AMA). Plasma triglyceride (TG) levels were 6-fold greater in these rats than in those fed and alcoho...

Purohit, V.; Russo, D.; Coates, P.M., 2005: Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. Alcoholic liver disease is a major cause of illness and death in the United States. In the initial stages of the disease, fat accumulation in hepatocytes leads to the development of fatty liver (steatosis), which is a reversible condition. If alco...

Anonymous, 2004: Symposium 'Role of Fatty Liver, Dietary Fatty Acid Supplements, and Obesity in the Progression of Alcoholic Liver Disease,' Bethesda, Maryland, USA, October 2003. This journal issue contains 11 articles discussing the role of fatty liver, dietary fatty acid supplements and obesity in the pathogenesis and progression of human and experimental alcoholic fatty liver disease. The molecular mechanisms of alcohol...

Anonymous, 2005: Role of Fatty Liver, Dietary Fatty Acid Supplements, and Obesity in the Progression of Alcoholic Liver Disease. October 3, 2003, Bethesda, Maryland, USA. Proceedings of a meeting. Alcohol 34(1): 1-87

Aoun, M.; Fouret, G.; Michel, Fçoise.; Bonafos, Béatrice.; Ramos, J.; Cristol, J-Paul.; Carbonneau, M-Annette.; Coudray, C.; Feillet-Coudray, C., 2012: Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease. No data are reported on changes in mitochondrial membrane phospholipids in non-alcoholic fatty liver disease. We determined the content of mitochondrial membrane phospholipids from rats with non alcoholic liver steatosis, with a particular attenti...

Stanko R.T.; Adibi S.A., 1977: Prevention of ethanol induced fatty liver by dietary additives measurement of fatty acid oxidation pyruvate decarboxylase and tri carboxylic acid cycle activity. Clinical Research 25(3): 469A

Zhang, Y.; Tang, C-lin.; Tian, Y.; Yuan, H-zhou.; Yang, H.; Tang, N-zhen.; Gao, R-qi.; Cao, J., 2016: Effects of Electroacupunctrue Combined with Dietary Control on Peroxisome Proliferator-activa- ted Receptor-α, and Liver Fatty Acid-binding Protein Levels in Non-alcoholic Fatty Liver Disease Rats. To observe the effect of electroacupunctrue (EA) intervention or EA combined with dietary control on peroxisome proliferator-activated receptor (PPAR)-α, and liver fatty acid-binding protein (L-FABP) levels in non-alcoholic fatty liver disease (N...

Abenavoli, L., 2015: Non-alcoholic fatty liver disease and beneficial effects of dietary supplements. I read with great interest the review published by Eslamparast et al, on the dietary supplements with hepato-protective properties, and their proposed mechanisms to protect against non-alcoholic fatty liver disease. In this way, recently, our stud...

Rahimlou, M.; Ahmadnia, H.; Hekmatdoost, A., 2015: Dietary supplements and pediatric non-alcoholic fatty liver disease: Present and the future. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. High prevalence of pediatric obesity and sedentary lifestyle has augmented the incidence of NAFLD in children. Obesity is associated with an increased...

Olpin, S.E.; Bates, C.J., 1982: Lipid metabolism in riboflavin-deficient rats. 1. Effect of dietary lipids on riboflavin status and fatty acid profiles. 1. The increase in activation coefficient (stimulated: basal activity) of erythrocyte NAD(P)H2: glutathione oxidoreductase (EC 1.6.4.2) and reduction in hepatic flavin concentration which occurred in riboflavin-deficient weanling rats were not mar...