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Variation in plasma ketone bodies during a 24-hour fast in normal and in hypoglycemic children: relationship to age



Variation in plasma ketone bodies during a 24-hour fast in normal and in hypoglycemic children: relationship to age



Journal of Pediatrics 98(6): 904-908



Variations in blood ketone bodies, blood glucose and insulin were studied in 19 normal and 14 hypoglycemic children, 4 mo.-13 yr of age, during a 24-h fast. Except in 4 patients (2 with hyperinsulinism and 2 with congenital defect in ketogenesis), a significant increase in blood ketone bodies was observed in controls and patients. A progressive decrease in glucose concentrations was observed up to but not after 20 h. A highly negative correlation between blood ketone bodies and blood glucose was found, with a large dispersion of blood ketone bodies, especially for those corresponding to the blood glucose between 45-65 mg/dl. This dispersion was consistently reduced in a homogeneous age group of 4-6 yr with similar glucose values. There was a positive correlation between age and blood glucose from hour 21 on, and an inverse relationship between age and blood ketone bodies from hour 15 on. The same high inverse relationship between age and blood ketone bodies was observed when the variable of glucose concentration was factored out, demonstrating that the variation in blood ketone bodies is related to age. These findings need to be taken into account in the interpretation of fasting blood ketone bodies, especially when used as an aid in the diagnosis of the various forms of childhood hypoglycemia, and of hypoketotic states.

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Accession: 001030442

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PMID: 7014812

DOI: 10.1016/s0022-3476(81)80583-5


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