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A functional homologue of mammalian secretory component exists in chickens



A functional homologue of mammalian secretory component exists in chickens



European Journal of Immunology 13(7): 566-570



The existence of a molecule in chickens homologous to the secretory component of mammals has long been in dispute. An intravenous injection of [14C]fucose was given to chickens as a marker for newly synthesized glycoproteins and then unlabeled human IgA was injected intravenously half an hour later. It was shown that the human IgA subsequently appeared in the bile of the chickens combined with a [14C]fucose-labeled molecule; the chicken IgA in these bile samples was similarly labeled. Radiolabeled human secretory IgA was not transported in large amounts across the chicken liver in vivo and neither was purified chicken bile IgA. These results indicate that a molecule exists in chickens which behaves in a manner analogous to mammalian secretory component.

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Accession: 001038015

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PMID: 6409654

DOI: 10.1002/eji.1830130710


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