+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

A functional homologue of mammalian secretory component exists in chickens

A functional homologue of mammalian secretory component exists in chickens

European Journal of Immunology 13(7): 566-570

The existence of a molecule in chickens homologous to the secretory component of mammals has long been in dispute. An intravenous injection of [14C]fucose was given to chickens as a marker for newly synthesized glycoproteins and then unlabeled human IgA was injected intravenously half an hour later. It was shown that the human IgA subsequently appeared in the bile of the chickens combined with a [14C]fucose-labeled molecule; the chicken IgA in these bile samples was similarly labeled. Radiolabeled human secretory IgA was not transported in large amounts across the chicken liver in vivo and neither was purified chicken bile IgA. These results indicate that a molecule exists in chickens which behaves in a manner analogous to mammalian secretory component.

(PDF emailed within 0-6 h: $19.90)

Accession: 001038015

Download citation: RISBibTeXText

PMID: 6409654

DOI: 10.1002/eji.1830130710

Related references

SecA, an essential component of the secretory machinery of Escherichia coli, exists as homodimer. Biochemical and Biophysical Research Communications 174(1): 211-216, 1991

Peculiar secretory IgA system identified in chickens. II. Identification and distribution of free secretory component and immunoglobulins of IgA, IgM, and IgG in chicken external secretions. Journal of Immunology 115(4): 998-1001, 1975

Characterization of epitopes of human secretory component on free secretory component, secretory IgA, and membrane-associated secretory component. Journal of Immunology 133(4): 2116-2125, 1984

Studies on human secretory IgA. II. Comparative studies on a fragment of secretory component derived from secretory IgA and fragments obtained by enzymatic digestion of free secretory component. Immunochemistry 10(2): 73-80, 1973

Bacillus subtilis Ffh, a homologue of mammalian SRP54, can intrinsically bind to the precursors of secretory proteins. Biochemical and Biophysical Research Communications 227(3): 762-767, 1996

Production of secretory immunoglobulin A in a single mammalian cell Role of alpha chain domains in its assembly with J chain and secretory component. FASEB Journal 12(5): A913, March 20, 1998

Distribution of immunoglobulin and secretory component containing cells in chickens. American Journal of Veterinary Research 38(8): 1227-1230, 1977

Characterization of epithelial elements in human major salivary glands by functional markers: localization of amylase, lactoferrin, lysozyme, secretory component, and secretory immunoglobulins by paired immunofluorescence staining. Journal of Histochemistry and Cytochemistry 30(7): 657-666, 1982

Component X of mammalian pyruvate dehydrogenase complex: structural and functional relationship to the lipoate acetyltransferase (E2) component. Febs Letters 253(1-2): 11-15, 1989

Enhancing effect of Bacillus subtilis Ffh, a homologue of the SRP54 subunit of the mammalian signal recognition particle, on the binding of SecA to precursors of secretory proteins in vitro. Journal of Biochemistry 125(1): 151-159, 1999

Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. EMBO Reports 5(6): 613-619, 2004

Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK. Plos One 8(3): E57630, 2013

Rapid effect of ovarian hormones on secretory component in uterine secretions of the rat the involvement of rna synthesis in secretory component production. Peeters, H (Ed ) Protides Of The Biological Fluids; Proceedings Of The Colloquium, Vol 32 Immunoglobulins, Tumor Markers And Targeting Advances in Separation Of Protides; Brussels, Belgium, 1984 Xxxv+1202p Pergamon Press: Oxford, England; New York, N Y , Usa Illus 255-258, 1985

Differences between the in vitro combinations of secretory component and immuno globulin polymers by enumeration of secretory component epitopes. Immunology Letters 7(4): 195-202, 1984

Cleavage of membrane secretory component to soluble secretory component occurs on the cell surface of rat hepatocyte monolayers. Journal of Cell Biology 104(6): 1725-1734, 1987