+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A mathematical model for nutrition in toxicology

A mathematical model for nutrition in toxicology

Nutrition Reports International 26(1): 115-120

Nutritional status can have profound effects on the response of an organism to drugs or other chemicals. It would be useful to have a mathematical model which predicted drug response over a wide range of administration and variation in nutritional status of the host. The 2 principal models currently in use for the description and prediction of dose-response relationships are the log-dose transformation and the probit transformation. Both models are limited due to an inability to describe or predict responses over a wide range of doses and a lack of theoretical basis. The saturation kinetics model has mathematical significance in that it can describe a wider range of responses and biological significance in that it can be related to biological structure and function. The saturation kinetics model offers several new indexes of comparison for dose-response curves and definitions for commonly used terms such as efficacy and potency.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 001038328

Download citation: RISBibTeXText

Related references

A mathematical model of predation based upon the theory of nutrition kinetics 2. a nutrition structure of the predator population and its functional response to the prey. Ecological Modelling 40(1): 67-76, 1988

A nutrition mathematical model to account for dietary supply and requirements of energy and other nutrients for domesticated small ruminants: The development and evaluation of the Small Ruminant Nutrition System. Small Ruminant Research 89(2-3): 174-184, 2010

Application of a growth model in animal nutrition 1. mathematical bases. Archiv fuer Tierernaehrung 30(5): 427-436, 1980

Grape Nutrition Management Service: a mathematical model and database. Acta Horticulturae (640): 45-49, 2004

A mathematical model of predation based upon the theory of nutrition kinetics. Ecological Modelling 28(1-2): 155-164, 1985

Mathematical model of the uptake of radioactivity from the viewpoint of nutrition ecology. Journal of Radiation Research 18(1): 61, 1977

Mathematical model of mean age, mean arsenic dietary dose and age-specific prevalence rate from endemic chronic arsenic poisoning: a human toxicology study. Zentralblatt für Bakteriologie. 1. Abt. Originale B Hygiene Krankenhaushygiene Betriebshygiene Praventive Medizin 170(5-6): 402-408, 1980

Kiwifruit nutrition management service: A mathematical model and database for commercial consultancy. Acta Horticulturae 276: 79-86, 1990

Method of evaluating actual nutrition of organized groups of subjects using a mathematical model. Voprosy Pitaniya ( 5): 46-49, 1989

Mathematical modeling in nutrition: constructing a physiologic compartmental model of the dynamics of beta-carotene metabolism. Advances in Food and Nutrition Research 40: 25-54, 1996

About the interpretation and mathematical model of histochemical results by stochastical procedure with the QUANTIMET. I. Base for a mathematical model. Acta Histochemica 49(1): 95, 1974

A mathematical model study on the management of forage crop productivity. Note I: Research on maize carried out in 1986. Part II: Studies on mathematical model testing. Annali dell' Istituto Sperimentale per la Nutrizione delle Piante1986 1988; 13(2): 14-30, 1985

The development and evaluation of a mathematical nutrition model to predict digestible energy intake of broodmares based on body condition changes. Journal of Animal Science 91(5): 2169-2177, 2013

New research avenues in toxicology: 7-gas N-Gas Model, toxicant suppressants, and genetic toxicology. Toxicology 115(1-3): 89-106, 1996

World review of nutrition and dietetics vol 29 toxicology and nutrition symposium alfort france november 17 19 1976. World Review of Nutrition and Dietetics 190, 1978