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Body composition and adiposity in LH-lesioned and pair-fed obese Zucker rats



Body composition and adiposity in LH-lesioned and pair-fed obese Zucker rats



American Journal of Physiology 242(6): E437-E444



Groups of lean and obese Zucker rats, sustaining lesions of the lateral hypothalamus (LH) at 10 weeks old, maintained bodyweight at 72% of that of nonlesioned controls until killed at 32 weeks. Pairfeeding nonlesioned rats to the intakes of lean and obese LH-lesioned rats produced a reduction in adipocyte number similar to that caused by lesions. Neither the lean nor obese LH-lesioned rats displayed an increase in cell number when given a palatable diet which increased carcass lipids.

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Accession: 001050149

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PMID: 7046461



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