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Characterization of a murine model (beige) for a natural killer cell immunodeficiency in the Chediak-Higashi syndrome of man


, : Characterization of a murine model (beige) for a natural killer cell immunodeficiency in the Chediak-Higashi syndrome of man. Progress in Clinical and Biological Research 94: 315-325

A review of immune function in mice homozygous for the beige mutation (bgJ/bgJ).


Accession: 001053343

PMID: 7122620

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Related references

Ito, M.; Sato, A.; Tanabe, F.; Ishida, E.; Takami, Y.; Shigeta, S., 1989: The thiol proteinase inhibitors improve the abnormal rapid down-regulation of protein kinase C and the impaired natural killer cell activity in (Chediak-Higashi syndrome) beige mouse. Protein kinase C (PKC) is essential in intracellular signal transduction for various cell functions including natural killer (NK) cell activity. This enzyme is hydrolysed by calpain, which is Ca2+-dependent thiol proteinase. We showed here that in...

Brahmi, Z., 1983: Nature of natural killer cell hyporesponsiveness in the Chediak-Higashi syndrome. Two unrelated Chediak-Higashi syndrome (CHS) patients in the prelymphomatous phase and their families were tissue typed and tested for their immune functions including natural killer cell (NK) activity. NK activity was assessed by the conventional...

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Marquis G.; Montplaisir S.; Pelletier M.; Mousseau S.; Auger P., 1985: Genetic resistance to murine cryptococcosis the beige mutation chediak higashi syndrome in mice. The influence of the bgJ and bg2J mutations on the susceptibility of mice to experimental cryptococcosis was studied in inbred mice of the C57BL/6J and C3H/HeJ strains. Although infected animals with the bg/bg genotype had a significantly shorter...

Rook A.H.; Grimm E.A.; Leavitt R.Y.; Fauci A.S., 1985: Interleukin 2 in vitro corrects the defect in natural killer cell activity in the chediak higashi syndrome. Clinical Research 33(2 PART 1): 387A

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