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Histological and histochemical characterisation of mammary gland tissue of cows infected with foot-and-mouth disease by contact exposure



Histological and histochemical characterisation of mammary gland tissue of cows infected with foot-and-mouth disease by contact exposure



Research in Veterinary Science 35(1): 106-113



Foot-and-mouth disease virus was observed to replicate in secretory epithelial cells of bovine mammary gland alveoli as a result of systemic infection initiated by exposure to infected animals. Viral antigens were demonstrated using fluorescent antibody and immunoperoxidase labeling techniques before the development of signs of clinical disease. Labeled antigens were observed associated with cytoplasmic-like fragments in luminal membrane limited structures. Histologically, lesions of the alveolar secretory epithelium consisted of focal necrosis of these cells which eventually sloughed into the lumen.

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Accession: 001085238

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PMID: 6312518



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