+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Host and parasite factors influencing the expression of cutaneous leishmaniasis

Host and parasite factors influencing the expression of cutaneous leishmaniasis

Ciba Foundation Symposium 99: 174-189

Host and parasite factors influencing the expression of cutaneous leishmaniasis were investigated in two murine models of different leishmanial diseases. The role of B lymphocytes in the uncontrolled disease manifested by BALB/c mice infected with cutaneous leishmaniasis was investigated in animals of this inbred strain depleted of B cells by neonatal administration of anti-mouse mu-chain antisera. Whereas non-depleted control mice developed chronic metastatic infections with both Leishmania tropica and Leishmania mexicana and showed depressed delayed-type hypersensitivity when skin-tested with leishmanial antigens, the mu-suppressed mice controlled their initial lesions while displaying strong antigen-specific delayed-type hypersensitivity. These findings reveal an inverse relationship between humoral and cell-mediated immunity in the expression of chronic leishmaniasis and suggest that B lymphocytes or their products regulate the delayed-type hypersensitivity response to leishmanial infection. In a separate study, healing and chronic strains of Leishmania were compared for their susceptibility to killing by lymphokine-activated mouse peritoneal macrophages. Whereas amastigotes of the healing strains were readily destroyed by these macrophages, amastigotes of two Leishmania strains, previously shown to produce chronic infections in mice, were resistant to killing by the same cells. These findings suggest that the ability of certain leishmanial strains to induce chronic disease may result from their capacity to evade intracellular destruction by activated macrophages.

(PDF emailed within 1 workday: $29.90)

Accession: 001085608

Download citation: RISBibTeXText

PMID: 6227463

Related references

Host and parasite factors regulating the development of CD4+ T-cell subsets in experimental cutaneous leishmaniasis. Research in Immunology 142(1): 32-36, 1991

Host and parasite factors regulating the development of cd4 positive t cell subsets in experimental cutaneous leishmaniasis. Research in Immunology 142(1): 32-36, 1991

Host parasite relationships in cutaneous leishmaniasis. Zuckerman, Avivah (edamic Aspects Of Host-Parasite Relationships, Vol. Ii. X 225p. Illus. Halsted Press, A Division Of John Wiley And Sons: New York, N.y., U.s.a.; Israel Universities Press, A Division Of Keter Publishing House Jerusalem Ltd: Jerusalem, Israel. Isbn 0-470-98430-9; Isbn 0-7065-1523-4. 177-189, 1975

Imaging of the host/parasite interplay in cutaneous leishmaniasis. Experimental Parasitology 126(3): 310-317, 2010

Visceral and cutaneous leishmaniasis comparative ultrastructure of host-parasite interactions. Journal of the Egyptian Society of Parasitology 25(3): 861-876, 1995

Morphological aspects of host parasite interrelationships in experimental cutaneous leishmaniasis in hamsters. Meditsinskaya Parazitologiya i Parazitarnye Bolezni 44(6): 682-687, 1975

Host-parasite relations between Pieris brassicae L. and its parasite Apanteles glomeratus L. and factors influencing their resistance to insecticides. Byull. vses. nauch.-issled. Inst. Zasch. Rast., 14: 3-7, 1970

Natural history, clinical evolution, and the host-parasite interaction in New World cutaneous leishmaniasis. Clinics in Dermatology 14(5): 433-450, 1996

PCR detection and sequencing of parasite ITS-rDNA gene from reservoirs host of zoonotic cutaneous leishmaniasis in central Iran. Parasitology Research 103(6): 1273-1278, 2008

Factors influencing infection patterns of trophically transmitted parasites among a fish community: host diet, host-parasite compatibility or both?. Journal of Fish Biology 79(2): 466-485, 2011

Electron microscopical studies on cutaneous leishmaniasis in Ethiopia. II. Parasite and host cell differences between the localized and the diffuse form. Acta Tropica 44(4): 395-407, 1987

Host susceptibility factors to cutaneous leishmaniasis. Frontiers in Bioscience 3: D1171-D1180, 1998

Factors in host parasite interactions and immunological unresponsiveness in leishmaniasis. Current Science (Bangalore) 61(7): 460-466, 1991

Enhancement of experimental cutaneous leishmaniasis by Leishmania molecules is dependent on interleukin-4, serine protease/esterase activity, and parasite and host genetic backgrounds. Infection and Immunity 79(3): 1236-1243, 2011