EurekaMag.com logo
+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Host protective antibodies and serum immunoglobulin isotypes in mice chronically infected or repeatedly immunized with the nematode parasite Nematospiroides dubius



Host protective antibodies and serum immunoglobulin isotypes in mice chronically infected or repeatedly immunized with the nematode parasite Nematospiroides dubius



Immunology 48(1): 37-47



The nematode parasite Nematospiroides dubius survives to give a chronic primary infection in mice. However, mice subjected to weekly infections of 125 larvae, interspersed by treatment with an anthelmintic to prevent the accumulation of lethal numbers of adult worms in the intestine, develop host-protective antibodies in their serum. The protective effect of these antibodies was demonstrated by passive transfer to naive recipients or to mice already adoptively immunized with immune mesenteric lymph node cells (IMLNC). Sera were first shown to exhibit protective activity during the third and fourth weeks of the multiple immunizing infection, reaching a peak level by week six beyond which there was no further increase in protective activity. This increase was correlated with a ten-fold, concurrent rise in serum IgG1 levels. None of the other immunoglobulin isotypes underwent comparable changes in concentration nor could they be correlated with the pattern of appearance of host-protective antibodies in the sera of donor mice. This suggested that host protective antibodies were of the IgG1 class. CFLP and C57BL10 mice (the latter is a weak responder strain) both had high levels of host-protective antibodies in their serum. However when the sera from NIH mice (a strong responder strain) were compared, they exhibited far less protective activity on passive transfer to recipient mice, although when given together with IMLNC, serum from multiply-immunized NIH mice enhanced the protective effect of IMLNC synergistically. When primary infection serum was assayed in this passive/adoptive transfer model, no host-protective antibodies could be demonstrated, even with pools of primary infection serum taken 10 and 17 weeks after infection. These results are discussed with respect to the possible mechanisms by which N. dubius evades the host immune system to give rise to long-lasting primary infections in mice.

(PDF emailed within 1 workday: $29.90)

Accession: 001085637

Download citation: RISBibTeXText

PMID: 6848453



Related references

Localization of immuno globulin g 1 producing cells within a hyper stimulated lymph node of mice infected with an intestinal nematode parasite nematospiroides dubius. Immunology Letters 1(3): 137-140, 1979

Nematospiroides dubius: mechanisms of host immunity. I. Parasite counts, histopathology, and serum transfer involving orally or subcutaneously sensitized mice. Experimental Parasitology 35(3): 434-452, 1974

Induction of immunity in mice to the nematode parasite, Nematospiroides dubius. Australian Journal of Experimental Biology and Medical Science 55(4): 393-400, 1977

The population dynamics of heligmosomoides polygyrus nematospiroides dubius in mice the consequences of parasite induced host mortality and the effect of the host response on parasite survival and fecundity. Parasitology 89(2): LVI, 1984

Nematospiroides dubius mechanisms of host immunity part 1 parasite counts histo pathology and serum transfer involving orally or sub cutaneously sensitized mice. Experimental Parasitology 35(3): 434-452, 1974

Genetic variation and host-parasite relations: Nematospiroides dubius in mice. Journal of Parasitology 77(6): 884-889, 1991

Observations on host-parasite relations between laboratory mice and Nematospiroides dubius Baylis. Jour Parasitol 29(5): 303-311, 1943

Effect of host sex on passive immunity in mice infected with Nematospiroides dubius. International Journal for Parasitology, 85: 359-364, 1978

Nematospiroides dubius: passive transfer of protective immunity to mice with monoclonal antibodies. Experimental Parasitology 66(1): 7-12, 1988

Basal metabolic rate and lipid and liver glycogen in mice infected by the nematode Nematospiroides dubius. International Journal for Parasitology 4(3): 301-305, 1974

Nematospiroides dubius in mice selected for liability to infection modification of parasite biology through host selection. International Journal for Parasitology 12(6): 573-578, 1982

Time course for the formation of effective antibodies in different strains of mice infected with nematospiroides dubius. Parasitology 84(1): XI-XII, 1982