+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Host-parasite interactions which influence the virulence of Trypanosoma (Trypanozoon) brucei brucei organisms



Host-parasite interactions which influence the virulence of Trypanosoma (Trypanozoon) brucei brucei organisms



Acta Tropica 40(1): 11-18



Subclones were prepared in mice from T. b. brucei ILTat 1.4 parasites. Subclones which did not differentiate to stumpy forms in mice were highly virulent and did not stimulate detectable antibody responses. A subclone which did give rise to stumpy forms in mice, was less virulent and did stimulate an antibody response specific for the trypanosome surface glycoprotein. Clones and subclones of T.b. brucei parasites which did not give rise to stumpy forms in mice, did give rise to stumpy forms in Bovidae. Plasma from cattle infected with those parasites did not stimulate differentiation of T.b. brucei parasites in mice. Murine pleomorphic and monomorphic T.b. brucei parasites retained their respective phenotypes in co-infected mice. Both types of parasites were equally pleomorphic in Bovidae. We conclude that some clones of T.b. brucei remain monomorphic in mice as a result of a high avidity interaction between slender forms and host molecules which inhibit differentiation of T.b. brucei parasites.

(PDF emailed within 1 workday: $29.90)

Accession: 001085682

Download citation: RISBibTeXText

PMID: 6134448



Related references

Comparison of the infectivity and virulence of a series of closely related trypanosoma brucei trypanozoon brucei antigenic types for mice abstract. Transactions of the Royal Society of Tropical Medicine & Hygiene 63(1): 123, 1969

Regulation of parasite-specific antibody responses in resistant (C57BL/6) and susceptible (C3H/HE) mice infected with Trypanosoma (trypanozoon) brucei brucei. Parasite Immunology 8(5): 425-442, 1986

Host-parasite interactions: regulation of parasitaemia in animals infected with Trypanosoma brucei organisms. Trypanotolerance and animal production Proceedings of the Workshop 10-14 May 1982, Lome et Avetonou, Togo Schriftenreihe der GTZ No116: 135-142, 1982

The dog as reservoir host of Trypanosoma (Trypanozoon) brucei gambiense: a comparative study on the susceptibility of European and West African dogs to T. gambiense and T. brucei and on the course of infection. Der Hund als Reservoir fur Trypanosoma Trypanozoon brucei gambiense: Vergleichende Untersuchungen zur Empfanglichkeit fur T b gambiense Dutton, 1902 und T b brucei Plimmer and Bradford, 1899 und zum Infektionsverlauf bei einer europaischen und einer westafrikanischen Hunderasse: 113 pp., 1990

Filaments of Trypanosoma brucei: some notes on differences in origin and structure in two strains of Trypanosoma (Trypanozoon) brucei rhodesiense. Acta Tropica 33(2): 151-168, 1976

Infectivity and virulence of Trypanosoma (Trypanozoon) brucei to mice. Trop. Anim. Hlth Prod.: 2: 59-64, 1970

Purification and regulatory properties of phosphofructokinase from Trypanosoma (Trypanozoon) brucei brucei. Biochemical Journal 227(1): 113-124, 1985

Relationship between Eperythrozoon coccoides and Trypanosoma (Trypanozoon) brucei brucei in experimentally infected mice. Annals of Tropical Medicine and Parasitology 64(3): 325-328, 1970

Quantitation of genetic differences between trypanosoma brucei gambiense trypanosoma brucei rhodesiense and trypanosoma brucei brucei by restriction enzyme analysis of kinetoplast dna. Molecular & Biochemical Parasitology 3(2): 117-131, 1981

Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57B1/6) and susceptible (C3H/He) mice. Parasite Immunology 5(5): 465-478, 1983

Measure of molecular diversity within the Trypanosoma brucei subspecies Trypanosoma brucei brucei and Trypanosoma brucei gambiense as revealed by genotypic characterization. Experimental Parasitology 99(3): 123-131, 2002

Infectivity and virulence of Trypanosoma (Trypanozoon) brucei for mice. IV. Dissociation of virulence and variable antigen type in relation to pleomorphism. Journal of Comparative Pathology 89(4): 465-470, 1979

Proteases from Trypanosoma brucei brucei. Purification, characterisation and interactions with host regulatory molecules. European Journal of Biochemistry 238(3): 728-736, 1996

Infectivity and virulence of Trypanosoma (Trypanozoon) brucei to mice. 3. Effects of social stress. Trop. Anim. Hlth Prod, 2: 59-64, 1970

Infectivity and virulence of Trypanosoma (trypanozoon) brucei for mice. I. Comparison of two mouse strains. Journal of Comparative Pathology 78(3): 341-344, 1968