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How strict is the MHC restriction of T cells ?



How strict is the MHC restriction of T cells ?



Current trends in histocompatibility Volume 2 Biological and clinical concepts: 143-155



In an experiment involving 9 mouse strains of different H-2 haplotype, F1 hybrids and genetically thymus-deficient nude mice were immunised with vaccinia virus WR or lymphocytic choriomeningitis virus. Radiation and thymus-transfer chimaeras were formed also. It was found that histocompatible targets were lysed 30-100 times more efficiently than incompatible targets, as H-2b-immune T cells lysed infected H-2b targets at least 30-100 times better than infected H-2k targets.

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