+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunosuppression during Trypanosoma musculi infection in inbred strains of mice

Immunosuppression during Trypanosoma musculi infection in inbred strains of mice

Journal of Clinical and Laboratory Immunology 10(3): 151-154

Inbred strains of mice inoculated with T. musculi behaved as either sensitive (A/J, CBA/J and C3H/He/J) or relatively resistant (BALB/c, DBA/2, and C57B1/6) with respect to the magnitude of parasitaemia but not to the length of infection. Spleen cells from T. musculi infected C57B1/6 (resistant) and C3H/HeJ (sensitive) mice inhibited the response of normal spleen cells to PHA and ConA; this suppressive activity was concentrated in T-cells and was higher in the resistant mice. However, infection in T-cell-deprived C57B1/6 and C3H/HeJ mice, although more severe and of much longer duration than in the respective control mice, revealed that T-cells were not responsible for the natural resistance to T. musculi.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 001087193

Download citation: RISBibTeXText

PMID: 6601720

Related references

Differences in resistance to Trypanosoma musculi infection among strains of inbred mice. Infection and Immunity 33(2): 364-371, 1981

Response of inbred mice to infection with a new isolate of Trypanosoma musculi. Parasitology 107: 233-236, 1993

Effect of holothurin on Trypanosoma musculi infection in three strains of mice. Journal of Protozoology 28(2): 167-170, 1981

Immunological aspects of infection of 6 inbred strains of mice by 3 different strains of Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 80(2): 203-211, 1985

Immunological and nonimmunological control of severity of Trypanosoma musculi infections in C3H and C57BL/6 inbred mice. Infection and Immunity 57(6): 1647-1655, 1989

Trypanosoma congolense: inheritance of susceptibility to infection in inbred strains of mice. Experimental Parasitology 483: 364-374, 1979

The possible use of Trypanosoma musculi infection in mice as a screening test for potential Trypanosoma cruzi-active drugs. Zeitschrift für Parasitenkunde 67(3): 245-248, 1982

Cytokine profiles during acute Trypanosoma cruzi infection in inbred strains of mice. Journal of Immunology 150(8 Part 2): 69A, 1993

Dynamics of the phagocytic cells during the infection of two inbred strains of mice with trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 81(Suppl.): 144, 1986

Genetic control of susceptibility to trypanosoma congolense infection in inbred strains of mice. Zeitschrift Fuer Immunitaetsforschung: 341-342, 1978

Changes in the subsets of CD4+ T cells in Trypanosoma musculi infection: delay of immunological cure in young mice and the weak ability of aged mice to control the infection. International Immunology 6(8): 1107-1115, 1994

The effects of gossypol (a phytochemical) on the development of Trypanosoma musculi in two strains of mice. Virginia Journal of Science 49(1): 11-21, 1998

Trypanosoma musculi infection of nude mice. Proceedings of the 3rd International Workshop on nude mice, Montana State University, Bozeman, Montana, 6-9 September 1979 Volume 1 Invited lectures, infection, immunology: 111-122, 1982

Trypanosoma musculi infection in intact and thymectomized CBA mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 65(4): 424, 1971