Lipoprotein levels and tissue lipids in fatty-fibrous atherosclerosis induced in rabbits by two years' cholesterol feeding at a low level

Adams, C.W.; Miller, N.E.; Morgan, R.S.; Rao, S.N.

Atherosclerosis 44(1): 1-8


ISSN/ISBN: 0021-9150
PMID: 7115472
DOI: 10.1016/0021-9150(82)90047-8
Accession: 001095479

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A group of 12 young New Zealand White rabbits of the same breeding strain were fed on a diet with cholesterol 0.1% by weight. The resulting slight hypercholesterolaemia resolved after 4 to 5 months. Two rabbits which died during that period showed no gross or microscopic atherosclerosis. After 6 months, the dietary cholesterol was increased to 0.2%. In some rabbits that resulted in moderate hypercholesterolaemia. One rabbit which died at that time showed no atherosclerosis with a mean serum cholesterol 224 mg/100 ml. Just after one year, dietary cholesterol was increased to 0.3%; there was definite hypercholesterolaemia in some rabbits, but a few had mean serum cholesterol values around 40 to 60 mg/100 ml. In general, rabbits with established hypercholesterolaemia showed severe atherosclerosis, but often of a more fibrous and less cellular nature than is usual in rabbits. Aortic wall cholesterol content (on a wet weight basis) was correlated positively with serum cholesterol concentration and negatively with the ratio of high-density lipoprotein cholesterol to low-density lipoprotein plus very-low-density lipoprotein cholesterol.