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Neutralization of foot-and-mouth disease virus. II. Further parameters related to the sensitization of the 140S virion by antibody


, : Neutralization of foot-and-mouth disease virus. II. Further parameters related to the sensitization of the 140S virion by antibody. Journal of General Virology 62: 287-295

The reaction of aphthovirus (FMDV) with 12S subunit/140S virion cross-reactive (sensitizing) antibody was studied to elucidate the requirements for neutralization versus sensitization. The presence of sensitizing antibody in immune serum caused an atypical in vitro neutralization response curve and a non-neutralized fraction. Cell-associated (cytophilic) antibody was not present in the system.

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Accession: 001101794

PMID: 6292352

DOI: 10.1099/0022-1317-62-2-287

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