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Neutralization of foot-and-mouth disease virus. II. Further parameters related to the sensitization of the 140S virion by antibody

Journal of General Virology 62: 287-295

Neutralization of foot-and-mouth disease virus. II. Further parameters related to the sensitization of the 140S virion by antibody

The reaction of aphthovirus (FMDV) with 12S subunit/140S virion cross-reactive (sensitizing) antibody was studied to elucidate the requirements for neutralization versus sensitization. The presence of sensitizing antibody in immune serum caused an atypical in vitro neutralization response curve and a non-neutralized fraction. Cell-associated (cytophilic) antibody was not present in the system.

Accession: 001101794

PMID: 6292352

DOI: 10.1099/0022-1317-62-2-287

Related references

Hardy, M.M.; Moore, D.M., 1981: Neutralization of foot-and-mouth disease virus. I. Sensitization of the 140S virion by antibody also reactive with the 12S protein subunit. The in vitro interaction of foot-and-mouth disease virus (FMDV) with an immune serum resulted in a fraction of virus which failed to be neutralized. This inability of antibody to neutralize the entire population of a virus preparation was studied...

Brown, Fred, 1995: Antibody recognition and neutralization of foot-and-mouth disease virus. Seminars in Virology 6(4): 243-248

Samuilenko, A.Ia., 1978: Determination of the amount of the 140S-component of foot-and-mouth disease virus. Veterinariia: 43-45

Samuilenko, Aia, 1978: Determination of the amount of 140S component of the foot-and-mouth disease virus. Veterinariia (10) 43-45

Samuilenko, A.Ya, 1978: Quantitative determination of the 140S component of foot and mouth disease virus. Correlation coefficients were calculated for the amount of 140S antigen in relation to the complement fixing titre, before and after treatment of the viral suspension with Freon-113. Results for strain 1618 of type O, strain 22 of type A and strai...

Alonso-Fernandez, A.S.ael-Sondahl, M., 1975: Preparation and concentration of 140S, 12S and virus-infection--associated antigens from foot-and-mouth disease virus. Boletin 17 18 1-8

Fayet, M.T.; Fargeaud, D.; Louisot, P.; Stellmann, C.; Roumiantzeff, M., 1971: Physical chemical measurement of 140S particles of the foot-and-mouth disease virus. Annales de L'institut Pasteur 121(1): 107-118

Verdaguer, N.; Fita, I.; Domingo, E.; Mateu, M.G., 1997: Efficient neutralization of foot-and-mouth disease virus by monovalent antibody binding. Neutralization of an aphthovirus by monovalent binding of an antibody is reported. Foot-and-mouth disease virus (FMDV) clone C-S8c1 was neutralized by monoclonal antibody (MAb) SD6, which was directed to a continuous epitope within a major antigen...

McCullough, K.C.; Smale, C.J.; Carpenter, W.C.; Crowther, J.R.; Brocchi, E.; D.S.mone, F., 1987: Conformational alteration in foot-and-mouth disease virus virion capsid structure after complexing with monospecific antibody. A mechanism of neutralization of virus infectivity by antibody is described and related to the immune defences in vivo. The interaction of a particular monoclonal antibody with homologous foot-and-mouth disease virus alters the conformation of the...

Tekerlekov P.; Vasileva L.; Nikolova E.; Veleva E., 1985: A method for the quantitative determination of the immunizing 140s antigen of the foot and mouth disease virus. Attempts were made to work out a method for measuring the amount of the 140 S antigen in virus suspensions. Early postinfection sera were obtained from guinea pigs against the productional strains of the foot-and-mouth disease virus which were use...