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Organophosphate poisoning: modifications in acid base equilibrium and use of sodium bicarbonate as an aid in the treatment of toxicity in dogs

Organophosphate poisoning: modifications in acid base equilibrium and use of sodium bicarbonate as an aid in the treatment of toxicity in dogs

Veterinary and Human Toxicology 25(1): 1-3

Technical quality DDVP was injected i/p into 13 dogs at 30 mg/kg, a dose 100% lethal in 27 minutes. Monitoring of blood pH, arterial gases, and cholinesterase activity before and during the intoxication showed acidosis. The i/v injection of sodium bicarbonate produced recovery of the acid-base balance, improvement in the poisoned state, and survival of 84.6% of the patients.

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Accession: 001105861

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PMID: 6298988

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