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Chapter 1,107

Oxytetracyclines in cattle. A comparison between a conventional and a long-acting preparation

Xia, W.; Nielsen, P.; Gyrd-Hansen, N.

Acta Veterinaria Scandinavica 24(1): 120-128

1983


ISSN/ISBN: 0044-605X
PMID: 6869141
Accession: 001106320

Pharmacokinetics of oxytetracycline (OTC) were studied in 4 cows after administration of either a conventional (OTC-C) or a long-acting (OTC-LA) preparation. After intravenous administration of OTC-C the elimination half-life for OTC was 6 h. Intramuscular injection of OTC-C and OTC-LA resulted in almost identical plasma concentrations of OTC with peak values after 6-8 h. For both preparations the bioavailability after i/m administration was 100%, and about 60% of the dose was excreted in the urine during the first week. Plasma concentrations above 0.5 mu g/ml were with both preparations maintained for approximately 60 h, indicating no retard effect of OTC-LA as compared to OTC-C.

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