Pathogenesis of mouse scrapie: evidence for spread of infection from central to peripheral nervous system
Kimberlin, R.H.; Field, H.J.; Walker, C.A.
Journal of General Virology 64 Pt 3: 713-716
ISSN/ISBN: 0022-1317 PMID: 6298352 DOI: 10.1099/0022-1317-64-3-713
The onset of replication was studied in spinal cord, dorsal root ganglia and spinal nerves of CW mice infected i/p with the 139A strain of scrapie. The patterns obtained suggest a centrifugal spread of infection from central to peripheral nervous systems. Infectivity titres in the peripheral nervous system reached a plateau long before the end of the incubation period, and the maximum titres were much lower than in the central nervous system.