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Pathogenesis of mouse scrapie: evidence for spread of infection from central to peripheral nervous system

Kimberlin, R.H.; Field, H.J.; Walker, C.A.

Journal of General Virology 64 Pt 3: 713-716

1983

ISSN/ISBN: 0022-1317
PMID: 6298352
DOI: 10.1099/0022-1317-64-3-713
Accession: 001107020
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The onset of replication was studied in spinal cord, dorsal root ganglia and spinal nerves of CW mice infected i/p with the 139A strain of scrapie. The patterns obtained suggest a centrifugal spread of infection from central to peripheral nervous systems. Infectivity titres in the peripheral nervous system reached a plateau long before the end of the incubation period, and the maximum titres were much lower than in the central nervous system.

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