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Stimulatory effect of short chain fatty acids on the epithelial cell proliferation in rat large intestine

Sakata, T.; Von Engelhardt, W.

Comparative Biochemistry and Physiology. A Comparative Physiology 74(2): 459-462

1983

ISSN/ISBN: 0300-9629
PMID: 6131789
DOI: 10.1016/0300-9629(83)90631-x
Accession: 001127615
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Short chain fatty acids [SCFA: acetate 75, propionate 35, butyrate 20 (mM)] introduced intraluminally into the colon increased the mitotic index and the labeling index of the large intestinal epithelial cells within 60 min fasted rats. Epithelia that lacked direct contact with SCFA were also stimulated. SCFA did not have such a stimulatory effect in vagotomized rats or in sympathectomized rats. Probably, SCFA stimulate epithelial cell proliferation in the large intestine of fasted rats via the autonomic nervous system.

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