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The luteotrophic complex in hysterectomized and pregnant goats


, : The luteotrophic complex in hysterectomized and pregnant goats. Journal of Physiology 342: 399-407

The pituitary hormones responsible for the maintenance of progesterone secretion by the corpus luteum were determined by replacement therapy in hysterectomy-hypophysectomized goats and in goats hypophysectomized on day 40 of pregnancy. Progesterone concentrations were 7.2 .+-. 0.81 ng/ml plasma (mean .+-. SE of mean) in intact goats during the luteal hase of the cycle and were 5.9 .+-. 0.56 ng/ml plasma after hysterectomy. After hypophysectomy of hysterectomized goats, treatment with 25 or 150 IU prolactin/day failed to maintain the corpora lutea, and progesterone concentrations fell to below 1.0 ng/ml plasma. Treatment with 1.0 mg luteinizing hormone (LH)/day after hypophysectomy maintained progesterone concentrations at 2.5 .+-. 0.48 ng/ml and treatment with 1.0 mg LH and 150 IU prolactin/day resulted in increased peripheral concentrations of 12.9 .+-. 1.66 ng progesterone/ml plasma. In goats hypophysectomized on day 40 of pregnancy treatment with 1.0 mg LH/day or 1.0 mg LH and 150 IU prolactin/day resulted in maintenance of the pregnancy and maintenance of high peripheral concentrations of 15.0 .+-. 1.77 ng progesterone/ml plasma, with no difference between the 2 treatments. The results show that LH is the pituitary hormone primarily responsible for the maintenance of progesterone secretion by the corpora lutea in the goat and that prolactin is synergistic with LH in stimulating this function. The difference in the pituitary luteotrophic complex between non-pregnant and pregnant animals may be explained if placental lactogen can substitute for prolactin in the luteotrophic complex of pregnant goats.

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Accession: 001139732

PMID: 6631741

DOI: 10.1113/jphysiol.1983.sp014858

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Related references

Buttle H.L., 1983: The luteotropic complex in hysterectomized and pregnant goats. The pituitary hormones responsible for the maintenance of progesterone secretion by the corpus luteum were determined by replacement therapy in hysterectomy-hypophysectomized goats and in goats hypophysectomized on day 40 of pregnancy. Progesteron...

Kornalijnslijper, E.; Bevers, M.M.; Van Oord, H.A.; Taverne, M.A.M., 1996: Plasma prolactin, growth hormone and progesterone concentrations in pseudo-pregnant, hysterectomized and pregnant goats. Journal of Reproduction & Fertility Abstract Series 0(18): 9

Kornalijnslijper, J.E.; Kemp, B.; Bevers, M.M.; van Oord, H.A.; Taverne, M.A., 1998: Plasma prolactin, growth hormone and progesterone concentrations in pseudopregnant, hysterectomized and pregnant goats. Jugular plasma prolactin (PRL), growth hormone (GH) and progesterone (P4) levels were estimated in goats under three different conditions with prolonged luteal function (P4 > or = 1 ng/ml): pseudopregnant animals (n = 4), goats hysterectomized...

Taverne, M.A.M.; Bevers, M.M.; Hesselink, J.W.; Van Den Brande, H.J.; Dieleman, S.J.; Van Oord, H.A., 1994: Evidence for a dominant role of prolactin in the luteotrophic complex of pseudopregnant goats. Eight pseudopregnant goats, characterized by the presence of aseptic fluid in the uterus and a persistent corpus luteum, were treated with 2 mg bromocriptine for 4 days to study the effects of a temporary decrease in prolactin secretion on plasma...

Garris, D.R., 1982: The luteotrophic effects of estradiol and prolactin in the absence of LH in the hysterectomized, pseudopregnant rat. The ability of oestradiol and prolactin to substitute for LH as luteotropins was investigated in pseudopregnant rats hysterectomised on the day of ovulation (day 1). All animals received a subcutaneous injection of oil, 1 mu g oestradiol or 150 mu...

Bosu W.T.K.; Serna Garibay J.A.; Barker C.A.V., 1979: Peripheral plasma levels of progesterone in pregnant goats and in pregnant goats treated with prostaglandin f 2 alpha. Prostaglandin [PG] or PG analogs were shown to be luteolytic in the pregnant goat. In this study the temporal changes in the plasma concentrations of progesterone during pregnancy and after administration of PGF2.alpha. to pregnant goats are descr...

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