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Cell-mediated immune response in Indian kala-azar and post-kala-azar dermal leishmaniasis

Haldar, J.P.; Ghose, S.; Saha, K.C.; Ghose, A.C.

Infection and immunity 42(2): 702-707

1983


ISSN/ISBN: 0019-9567
PMID: 6642649
Accession: 001169629

Indian kala azar (KA) and post-kala azar dermal leishmaniasis, cell-mediated immune (CMI) status determined by in vitro lymphocyte transformation experiments and by in vivo skin testing, results show impairment of CMI response in active KA which appears to be more specific to leishmania than generalized in nature, restoration of specific T-cell responsiveness was aided by antileishmanial drug therapy which resulted in reduction of antigenic load by parasite destruction and concomitant decrease in circulating antibody levels, particularly that of IgG class

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