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Chapter 1,187

Effect of amphotericin B on natural killer cell activity in vitro

Hauser, W.E.; Remington, J.S.

Journal of Antimicrobial ChemoTherapy 11(3): 257-262

1983


ISSN/ISBN: 0305-7453
PMID: 6841308
DOI: 10.1093/jac/11.3.257
Accession: 001186102

Incubation of murine peritoneal and spleen natural killer cells with amphotericin B at concentrations of 2.5, 5 and 10 mg/l in vitro, resulted in depression of their tumoricidal activity which had been augmented in vivo by infection with Toxoplasma gondii. In contrast, amphotericin B at the same concentrations had little or no effect on spontaneous natural killer cell activity in vitro. These in-vitro data suggest amphotericin B may have adverse effects on natural killer cell function in vivo.

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