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Effect of prior administration of suxamethonium on non-depolarising muscle relaxants in the dog

, : Effect of prior administration of suxamethonium on non-depolarising muscle relaxants in the dog. Research in Veterinary Science 36(1): 43-47

The depolarizing muscle relaxant suxamethonium (0.3 mg/kg) was administered to 6 dogs. At 50% return of the neuromuscular activity, as measured by the train-of-four technique, a non-depolarizing muscle relaxant was administered. Three drugs, alcuronium (0.1 mg/kg), gallamine (1.0 mg/kg) and pancuronium (0.06 mg/kg), were injected i.v. At the 50% return of neuromuscular activity, atropine and neostigmine were administered to reverse the neuromuscular block. The duration of action of the 3 non-depolarizing relaxants was reduced by the prior administration of suxamethonium.

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Accession: 001189084

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