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Histological modifications in the bursa fabricii and the thymus induced by cyclophosphamide and 6-mercaptopurine



Histological modifications in the bursa fabricii and the thymus induced by cyclophosphamide and 6-mercaptopurine



Revue Roumaine de Biologie Serie de Biologie Animale 27(1): 51-53



The thymus and bursa of chicks killed at intervals (1-28 days) after i/p injection of 3 mg/100 g body weight of cyclophosphamide daily for 1-3 days were examined histologically. Follicular atrophy and cellular depletion were seen 24 hours after the third injection and decrease in bursal folds and thymic lobules after 48 hours; regeneration occurred from 10 days, and was almost complete by 23 days.

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Accession: 001207652

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