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In vitro and in vivo inactivation of penicillin by penicillinase from Staphylococcus aureus of bovine mammary origin

In vitro and in vivo inactivation of penicillin by penicillinase from Staphylococcus aureus of bovine mammary origin

Kerala Journal of Veterinary Science 12(1): 31-35

A penicillinase-producing strain of Staphylococcus aureus was isolated from normal bovine udder. The penicillinase hydrolysed benzyl penicillin, penicillin V and ampicillin during incubation at 37 degrees C for 60 min, but had no effect on cephalosporin or cloxacillin. A crude enzyme preparation inhibited the effects of penicillin in vitro, and inactivation of penicillin was also demonstrated in vivo using mice challenged with Bacillus anthracis.

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Accession: 001210669

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