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Serum concentration of penicillin in the horse after repeated intramuscular injections of procaine penicillin G alone or in combination with benzathine penicillin and/or phenylbutazone

Serum concentration of penicillin in the horse after repeated intramuscular injections of procaine penicillin G alone or in combination with benzathine penicillin and/or phenylbutazone

American Journal of Veterinary Research 45(5): 1003-1007

Twenty-one adult horses were randomly assigned into 7 groups of 3 and were treated for 5 days with procaine penicillin G, benzathine penicillin, or phenylbutazone in various combinations and dosage schedules. Serum concentration of penicillin was measured serially over a 7-day period. The highest mean peak serum concentration was 2.06 micro g/ml. Comparable peak values were seen 2 to 4 hours after administration of 22 000 IU of procaine penicillin G/kg of body weight given once or twice daily.

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Accession: 001250656

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PMID: 6732003

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