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Serum oxytetracycline concentration in cows and calves after intramuscular injection of conventional and two long acting oxytetracycline preparations


Serum oxytetracycline concentration in cows and calves after intramuscular injection of conventional and two long acting oxytetracycline preparations



Refuah Veterinarith 39(4): 154-160



ISSN/ISBN: 0034-3153

Groups of cows and calves aged 5-7 weeks were injected i/m in the gluteal muscles with a conventional polyethylene glycol-base product of 10% oxytetracycline (OTC) (preparation A), an experimental polyethylene glycol-base long acting (LA) product of 10% OTC (preparation B), or a commercial polyvinyl pyrrolidone-base LA product of 20% OTC (preparation C). Treatments were given at 20 mg OTC/kg body mass, and serum drug concentrations were determined by microbiological assay in blood samples collected up to 96 h after treatment. The rate of drug absorption from the i/m injection site was faster with preparation C (t0.5 absor.=2.0-2.5h). Differences in the mean peak serum drug concentration (Cmax) after treatment with each preparation were not significant, but the time of reaching Cmax (Tmax) was shorter after treatment with preparation C (2-4 h) than after treatment with preparations A and B (6-8 h). Durations of serum drug concentrations more than 1.0 micro g/ml were 24-30, 36-44 and 56-60 h after treatment with preparations A, B, and C, respectively. Although preparation B could be considered long-acting in comparison to preparation A, duration of potentially effective serum OTC levels were approximately 24 h shorter than after treatment with preparation C. The three preparations were equally irritating, causing pain and swelling at the injection site.

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Accession: 001250736

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